Possible involvement of imidazoline binding sites on pancreatic beta cells in blood glucose change by several imidazoline agents
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چکیده
منابع مشابه
Behavioral involvement of imidazoline system.
The imidazoline system consists in imidazoline receptors I1, I2 and I3 and the active as well as that there are some endogenous ligands. We consider that one of the most important functions of this system is modulation of different types of behavior. Existent data show that I1 and I2 receptors have different effects on some behavior components, such as suicidal behavior, stress, anxiety, food i...
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Over the past few years, a vast amount of research has shed light on the pharmacology of imidazoline binding sites (I-BS). To date, at least three classes of imidazoline binding sites have been characterised in accordance to their localisation, drug selectivity, proposed signalling pathways and functional roles. The existence of these sites raises the question as to whether an endogenous modula...
متن کاملInvolvement of imidazoline system in drug addiction.
The imidazoline system (a concept which is barely over decades old) consists in imidazoline receptors I, I2 and I3 and their active endogenous ligands, the most important of which is agmatine. Brain contains both I1 and 12 of imidazoline receptors. One of the most important functions of this system is modulation of different behaviour components, such as suicidal behaviour, stress, anxiety, foo...
متن کاملVisualization of multiple imidazoline/guanidinium-receptive sites.
Compounds with an imidazoline or guanidinium moiety elicit a variety of stimulatory and inhibitory cell responses in both central and peripheral tissues. Many of these effects are mediated by interaction with alpha-adrenergic receptors, but these molecules also selectively recognize other membrane-bound proteins with high affinity. We used a functionalized derivative of the imidazoline molecule...
متن کاملIdentification of an imidazoline binding protein: Creatine kinase and an imidazoline-2 binding site
Drugs that bind to imidazoline binding proteins have major physiological actions. To date, three subtypes of such proteins, I(1), I(2) and I(3), have been proposed, although characterisations of these binding proteins are lacking. I(2) binding sites are found throughout the brain, particularly dense in the arcuate nucleus of the hypothalamus. Selective I(2) ligands demonstrate antidepressant-li...
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ژورنال
عنوان ژورنال: Japanese Journal of Pharmacology
سال: 2000
ISSN: 0021-5198
DOI: 10.1016/s0021-5198(19)48537-5